實驗室介紹
Introduction to the Circulation Laboratory
本實驗室主題在利用轉譯醫學平台及新穎動物模型，從心血管疾病出發，尋找瓣膜性心臟疾病、腫瘤心臟學、肺動脈高壓等跨領域議題的新型致病因子，以細胞、分生、基因轉殖動物進行相關基礎研究，闡明相關分子機轉，以精準醫療為概念，進一步探索預防及藥物介入的可能。
本實驗室在過去這幾年間，利用這樣的研究模式，探討以下研究主題：
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Using microRNAs and exosomes to study the cardiac adaptation and remodeling in pulmonary hypertension and mitral regurgitation
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Through whole exome sequencing (WES) and speckle tracking imaging to establish the predictive model of Cardio-Oncology
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The translational study of therapeutic interventions of novel drugs and compounds in cardiotoxicity and nephrotoxicity
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The applications of adipocyte derived stem cell (ADSC) ad hyperbaric oxygen (HBO) in hindlimb ischemia
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The hands-on workshop of small animal echo and lab techniques for residents and medical students
Introduction to the Circulation Laboratory
Our laboratory focuses on utilizing translational medicine platforms and novel animal models to investigate cardiovascular diseases, aiming to identify new pathogenic factors involved in interdisciplinary conditions such as valvular heart disease, cardio-oncology, and pulmonary hypertension. Through cellular, molecular, and transgenic animal studies, we conduct fundamental research to elucidate the underlying molecular mechanisms. Guided by the concept of precision medicine, we further explore potential strategies for prevention and pharmacological intervention.
Over the past few years, our laboratory has applied this research approach to explore the following research topics:
- Using microRNAs and exosomes to study the cardiac adaptation and remodeling in
pulmonary hypertension and mitral regurgitation - Through whole exome sequencing (WES) and speckle tracking imaging to establish
the predictive model of Cardio-Oncology - The translational study of therapeutic interventions of novel drugs and compounds
in cardiotoxicity and nephrotoxicity - The applications of adipocyte derived stem cell (ADSC) ad hyperbaric oxygen (HBO)
in hindlimb ischemia - The hands-on workshop of small animal echo and lab techniques for residents and
medical students