實驗室研究技術

超音波導引微創二尖瓣逆流大小鼠模型
Echo-guided mini-invasive mitral regurgitation (MR) model in rodents 

主動靜脈瘻管誘發肺動脈高壓模型

Aorto-venous shunt (AVS) induced PAH rodent model 

(左圖) 超音波導引微創二尖瓣逆流模型示意圖 (右圖) 術後瓣膜受損情況以及心臟超音波呈現心臟擴大及衰竭

(Left) Schematic diagram of the ultrasound-guided minimally invasive mitral regurgitation model. (Right) Postoperative valve damage and echocardiographic evidence of cardiac enlargement and heart failure.

(上圖 )主動脈(A)與下腔靜脈(V)瘻管手術示意圖 (下圖) 術後心臟超音波及切片呈現右心擴大及肺高壓 

(Top) Schematic diagram of arteriovenous fistula surgery between the aorta (A) andn inferior vena cava (V). (Bottom) Postoperative echocardiography and histology showing right heart enlargement and pulmonary hypertension.

小鼠心肌梗塞導致心衰竭模型

Mouse myocardial infarction (MI) induced heat failure model

主動脈窄縮手術誘使心臟肥大模型

Aortic constriction induced cardiac hypertrophy model

(左圖 ) 小鼠左冠狀動脈結紮示意圖 (右圖) 術後心臟超音波呈現心衰竭

(Left) Schematic diagram of left coronary artery ligation in mice. (Right) Postoperative echocardiography showing heart failure.

(左圖)小鼠主動脈窄縮手術示意圖 (右圖) 術後心臟超音波呈現心臟肥大及心衰竭

(Left) Schematic diagram of aortic constriction surgery in mice. (Right) Postoperative echocardiography showing cardiac hypertrophy and heart failure.

周邊動脈阻塞小鼠模型

Peripheral artery disease (PAD); limb ischemia mouse model

(左圖 ) 小鼠周邊動脈阻塞手術示意圖 (右上圖) 術前術後雷射都卜勒成像儀 (LDI) 比較 (右下圖) CD31呈現微血管密度

(Left) Schematic diagram of peripheral artery occlusion surgery in mice. (Top right) Pre- and postoperative comparison using laser Doppler imaging (LDI). (Bottom right) CD31 staining showing microvascular density.

PV loop Technique

啟動子設計及點突變

Promoter Design and Site-Directed Mutagenesis

流體環境細胞培養

Cell culture under flow

利用流體環境進行細胞培養，用以模擬活體內心血管在不同的血流下所產生的反應

Cell culture under fluidic conditions to simulate in vivo cardiovascular responses under different flow patterns.

粒線體研究

Mitochondrial studies

MicroCT

BD Rhapsody 單細胞分析系統

BD Rhapsody Single-Cell Analysis System

專門用於高效能的單細胞基因表達分析，從而提供有關細胞內部異質性和功能狀態的深入見解

Designed for high-performance single-cell gene expression analysis, providing deep insights into cellular heterogeneity and functional states.