研究成果

點擊數: 595

 

申   請   案：100案（2013年-2022年8月）

論          文：38篇（2013年-2021年）

專利與技轉：0 件

奇美醫院人體生物資料庫申請案清單(2019-2022/8)

編號 核准日期 題目 科別 主持人
CMBEC-108-001 108.03.12 台灣各種漿母細胞腫瘤的臨床病理特徵暨基因突變研究 解剖病理科 莊世松
CMBEC-108-002 108.03.20 鑑定高風險惡轉口腔癌前病變的微生物菌相以發展早期診斷之應用 牙醫部 蔣維凡
CMBEC-108-003 108.04.15 結合偵測體液中CEACAM6、非編碼長鏈RNA表現量和臨床因子分析以精準預測口腔癌前病變的復發及轉化成口腔癌 牙醫部 蔣維凡
CMBEC-108-004 108.05.01 伴隨淋巴癌之肉芽腫：一個具挑戰性的診斷及包括成人T細胞淋巴瘤/白血病的組織學範疇 解剖病理科 莊世松
CMBEC-108-005 108.05.21 MYD88突變應用於淋巴漿細胞淋巴癌所引起的肋膜積水的診斷 解剖病理科 莊世松
CMBEC-108-006 108.05.21 肋膜液自然殺手/T細胞淋巴瘤的臨床病理研究 解剖病理科 莊世松
CMBEC-108-007 108.04.29 探討頭頸部鱗狀上皮細胞癌的病人在疾病進展時甲基化的變化 血液腫瘤科 林建良
CMBEC-108-008 108.07.24 利用次世代定序尋找子宮內膜及子宮頸癌病人其突變基因和基因多型性與環境因子之關聯 婦產科 孫怡虹
CMBEC-108-009 108.08.13 探討COL11A1調控TGF-ß3致卵巢癌惡化的機轉及預後指標之開發 婦產科 黃順賢
CMBEC-108-010 108.08.16 探討泛素結合酶UBE2B調控O6-甲基化鳥嘌呤-去氧核醣核酸甲基轉移酶之機轉及與鼻咽癌病患存活率相關性 血液腫瘤科 蕭聖諺
CMBEC-108-011 108.12.10 探討LM04在非小細胞肺癌的角色 外科部 梁瑞麟
CMBEC-108-012 108.10.28 以多維體次世代定序分析鑑定高危險口腔癌前病變致病基因 牙科部 蔣維凡
CMBEC-109-001 109.01.06 台灣台南C型肝炎基因型第六型之分子流行病學研究 臨床病理科 吳麗卿
CMBEC-109-002 109.01.06 慢性C型肝炎病人接受口服抗病毒藥物治療失敗原因探討 內科部 郭行道
CMBEC-109-003 109.2.20 不可切除的局部惡化或轉移性泌尿上皮癌在台灣的治療結果及纖維母細胞生長因子受體（FGFR）變異率（ TOFTA） 血液腫瘤科 馮盈勳
CMBEC-109-004 109.3.24 結節外殺手/T細胞淋巴瘤的分子致病機轉暨PD-L1表現對預後的影響 解剖病理科 莊世松
CMBEC-109-005 109.3.25 應用蛋白體學與代謝體學尋找腦中風生物標誌 神經內科 吳明修
CMBEC-109-006 109.11.3 NCAPG過度表現於大腸直腸癌之臨床意義及致病機轉 一般外科 孫定平
CMBEC-109-007 109.11.3 比較腹腔鏡手術或機器手臂輔助手術治療術前同步放療之中低位直腸癌的前瞻性隨機對照試驗 台大醫院 梁金銅
CMBEC-109-008 109.11.3 探討台灣年輕女性三陰性乳癌多體（或組）學標記的臨床意義 中國附醫 黃至豪
CMBEC-109-009 109.11.3 探討黏液性結直腸腺癌多體(或組)學標記的臨床意義 中國附醫 張伸吉
CMBEC-109-010 109.11.3 研究BTK/HER2信號通路在HER2陽性乳腺癌生物特性角色: 調控T細胞的效應及逆轉賀癌平抗藥性的分子機制 臺北醫學大學 趙祖怡
CMBEC-109-011 109.11.3 探討ATMIN對於微星粒穩定大腸直腸癌的分子機轉及臨床意義 台大醫院 林本仁
CMBEC-109-012 109.11.3 研究巨細胞病毒US28基因型與大腸直腸癌病人預後之關連性 臺北榮總 詹宇鈞
CMBEC-109-013 109.11.3 EB病毒感染及變異基因與乳癌病人預後相關研究的驗證 馬偕醫院 楊博勝
CMBEC-109-014 109.11.10 三陰性乳癌細胞中LGR5蛋白參與侵襲與轉移的相關機制探討以及利用磁性輔助配適體快速篩選平台開發抑制LGR5活性之標靶化療配適體 秀傳醫院 朱旆億
CMBEC-109-015 109.11.17 表異質基因調控酵素及其抑制劑在個人化乳癌治療上的角色及應用 高雄醫學大學 潘美仁
CMBEC-109-016 109.11.17 探討與鑑定上泌尿道泌尿上皮癌中好發的基因變異:在病理生理上的
應用及臨床意義		 林口長庚醫院 馮思中
CMBEC-109-017 109.12.7 TMEM30A蛋白如何調控頭頸癌腫瘤細胞移行的機制研究 血液腫瘤科 蕭聖諺
CMBEC-110-001 110.4.6 利用HCV Ag簡化HCV篩檢流程提升檢測效能 臨床病理科 侯佳儀
CMBEC-110-002 110.5.13 台灣的皮膚gamma/delta T細胞淋巴瘤的臨床與病理特徵 病理部 莊世松
CMBEC-110-003 110.7.21 探討長鏈非編碼核糖核酸作為肺癌預後因子的角色 血液腫瘤科 蕭聖諺
CMBEC-110-004 110.8.9 以RNA定序預測三陰性乳癌患者的治療反應探討免疫檢查點抑制劑療法的抗藥機制 臺北榮總 曾令民
CMBEC-110-005 110.10.26 探討CEMIP2基因在膀胱泌尿上皮細胞癌之生物路徑與分子機制 醫研部 李健逢
CMBEC-110-006 110.12.20 ASPM調節FOXM1表達以在頭頸部鱗狀細胞癌中形成前幹信號迴路 牙科部 顏欽堉
CMBEC-111-001 111.1.8 一項臨床研究用的評估基質金屬蛋白酶-（MMP-1）檢測試劑組及快篩試劑組作為口腔癌輔助診斷之敏感度與特異性 口腔顎面外科 蔣維凡
CMBEC-111-002 111.2.15 探索初級纖毛形成與重覆性流產之關聯性 婦產部 溫仁育
CMBEC-111-003 111.7.15 探討FAT1基因突變影響口腔癌前病變癌化的轉譯研究：聚焦口腔癌疣狀增生 牙科部 蔣維凡
CMBEC-111-004 111.7.21 生醫大數據導引新機制藥物開發 臺北榮總 黃其晟
CMBEC-111-005 111.8.11 利用同源小鼠口腔癌細胞株探討Cd80在口腔癌的功能角色 國衛院 陳雅雯
CMBEC-111-006 111.8.24 探討化學治療在泌尿上皮癌對PD-L1和CSN5表現量的影響 血液腫瘤科 康乃文

 

奇美醫院人體生物資料庫論文發表清單

2013

  1. Wang HC, Chiang WF, Huang HH, Huang SK, Chiang HC. Promoter hypermethylation of the gene encoding heat shock protein B1 in oral squamous carcinoma cells. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Mar;115(3):376-84. (CMBEC-102-001)

2014

  1. Wu CC, Chang YT, Chang KP, Liu YL, Liu HP, Lee IL, Yu JS, Chiang WF. Salivary auto-antibodies as noninvasive diagnostic markers of oral cavity squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2014 Aug;23(8):1569-78. (CMBEC-103-004)

2015

  1. Takata K, Hong ME, Sitthinamsuwan P, Loong F, Tan SY, Liau JY, Hsieh PP, Ng SB, Yang SF, Pongpruttipan T, Sukpanichnant S, Kwong YL, Hyeh Ko Y, Cho YT, Chng WJ, Matsushita T, Yoshino T, Chuang SS. Primary cutaneous NK/T-cell lymphoma, nasal type and CD56-positive peripheral T-cell lymphoma: a cellular lineage and clinicopathologic study of 60 patients from Asia. Am J Surg Pathol. 2015 Jan;39(1):1-12. (CMBEC-103-022)
  2. Jhuang JY, Chang ST, Weng SF, Pan ST, Chu PY, Hsieh PP, Wei CH, Chou SC, Koo CL, Chen CJ, Hsu JD, Chuang SS. Extranodal natural killer/T-cell lymphoma, nasal type in Taiwan: a relatively higher frequency of T-cell lineage and poor survival for extranasal tumors. Hum Pathol. 2015 Feb;46(2):313-21. (CMBEC-103-022)
  3. Hung CC, Chien CY, Chiang WF, Lin CS, Hour TC, Chen HR, Wang LF, Ko JY, Chang CH, Chen JY. p22phox confers resistance to cisplatin, by blocking its entry into the nucleus. Oncotarget. 2015 Feb 28;6(6):4110-25. (CMBEC-104-004, CMBEC-104-011, CMBEC-104-012)

2016

  1. Feng YH, Chen WY, Kuo YH, Tung CL, Tsao CJ, Shiau AL, Wu CL. Elovl6 is a poor prognostic predictor in breast cancer. Oncol Lett. 2016 Jul;12(1):207-212. (CMBEC-103-010)
  2. Yu JS, Chen YT, Chiang WF, Hsiao YC, Chu LJ, See LC, Wu CS, Tu HT, Chen HW, Chen CC, Liao WC, Chang YT, Wu CC, Lin CY, Liu SY, Chiou ST, Chia SL, Chang KP, Chien CY, Chang SW, Chang CJ, Young JD, Pao CC, Chang YS, Hartwell LH. Saliva protein biomarkers to detect oral squamous cell carcinoma in a high-risk population in Taiwan. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11549-11554. (CMBEC-103-004)

2017

  1. Chen YT, Chen HW, Wu CF, Chu LJ, Chiang WF, Wu CC, Yu JS, Tsai CH, Liang KH, Chang YS, Wu M, Ou Yang WT. Development of a Multiplexed Liquid Chromatography Multiple-Reaction-Monitoring Mass Spectrometry (LC-MRM/MS) Method for Evaluation of Salivary Proteins as Oral Cancer Biomarkers. Mol Cell Proteomics. 2017 May;16(5):799-811. (CMBEC-103-004)
  2. Chen TW, Lee CC, Liu H, Wu CS, Pickering CR, Huang PJ, Wang J, Chang IY, Yeh YM, Chen CD, Li HP, Luo JD, Tan BC, Chan TEH, Hsueh C, Chu LJ, Chen YT, Zhang B, Yang CY, Wu CC, Hsu CW, See LC, Tang P, Yu JS, Liao WC, Chiang WF, Rodriguez H, Myers JN, Chang KP, Chang YS. APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism. Nat Commun. 2017 Sep 6;8(1):465. (CMBEC-103-004)
  3. Hsiao YC, Chi LM, Chien KY, Chiang WF, Chen SF, Chuang YN, Lin SY, Wu CC, Chang YT, Chu LJ, Chen YT, Chia SL, Chien CY, Chang KP, Chang YS, Yu JS. Development of a Multiplexed Assay for Oral Cancer Candidate Biomarkers Using Peptide Immunoaffinity Enrichment and Targeted Mass Spectrometry. Mol Cell Proteomics. 2017 Oct;16(10):1829-1849. (CMBEC-103-004)
  4. Li HY, Liang JL, Kuo YL, Lee HH, Calkins MJ, Chang HT, Lin FC, Chen YC, Hsu TI, Hsiao M, Ger LP, Lu PJ. miR-105/93-3p promotes chemoresistance and circulating miR-105/93-3p acts as a diagnostic biomarker for triple negative breast cancer. Breast Cancer Res. 2017 Dec 19;19(1):133. (CMBEC-104-015)

2018

  1. Chiang WF, Cheng TM, Chang CC, Pan SH, Changou CA, Chang TH, Lee KH, Wu SY, Chen YF, Chuang KH, Shieh DB, Chen YL, Tu CC, Tsui WL, Wu MH. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation. Oncogene. 2018 Jan 4;37(1):116-127. (CMBEC-104-010)
  2. Su YC, Feng YH, Wu HT, Huang YS, Tung CL, Wu P, Chang CJ, Shiau AL, Wu CL. Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression. Sci Rep. 2018 Apr 26;8(1):6586. (CMBEC-103-010)
  3. Wu MH, Luo JD, Wang WC, Chang TH, Hwang WL, Lee KH, Liu SY, Yang JW, Chiou CT, Chang CH, Chiang WF. Risk analysis of malignant potential of oral verrucous hyperplasia: A follow-up study of 269 patients and copy number variation analysis. Head Neck. 2018 May;40(5):1046-1056. (CMBEC-104-016, CMBEC-106-003)
  4. Chen BJ, Wang RC, Ho CH, Yuan CT, Huang WT, Yang SF, Hsieh PP, Yung YC, Lin SY, Hsu CF, Su YZ, Kuo CC, Chuang SS. Primary effusion lymphoma in Taiwan shows two distinctive clinicopathological subtypes with rare human immunodeficiency virus association. Histopathology. 2018 May;72(6):930-944. (CMBEC-107-002)
  5. 王傑田, 范美玲, 盧納密. 基因蛋白p63（TAp63）和p40（ΔNp63）的表現在乳癌分類診斷之研究. 台灣醫檢雜誌. 2018 33卷4期:1-7.

2019

  1. Pan ST, Wang RC, Kuo CC, Hsieh YC, Su YZ, Chuang SS. MYD88 L265P mutation analysis is a useful diagnostic adjunct for lymphoplasmacytic lymphoma with pleural effusion. Pathol Int. 2019 Oct;69(10):601-607. (CMBEC-108-005)
  2. Feng YH, Tung CL, Su YC, Tsao CJ, Wu TF. Proteomic Profile of Sorafenib Resistance in Hepatocellular Carcinoma; GRP78 Expression Is Associated With Inferior Response to Sorafenib. Cancer Genomics Proteomics. 2019 Nov-Dec;16(6):569-576. (CMBEC-103-010)

2020

  1. Chi LM, Hsiao YC, Chien KY, Chen SF, Chuang YN, Lin SY, Wang WS, Chang IY, Yang C, Chu LJ, Chiang WF, Chien CY, Chang YS, Chang KP, Yu JS. Assessment of candidate biomarkers in paired saliva and plasma samples from oral cancer patients by targeted mass spectrometry. J Proteomics. 2020 Jan 16;211:103571. (CMBEC-103-004)
  2. Hsu WL, Tsai MH, Wu CY, Liang JL, Lu JH, Kahle JS, Yu HS, Yen CJ, Yen CT, Hsieh YC, Huang YY, Lin LC, Tsai TF, Chen CH, Yoshioka T. Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by ultraviolet B. Aging Cell. 2020 Jan;19(1):e13075. (CMBEC-105-001)
  3. Chen JJ, Tung HD, Lee PL, Kuo HT, Sheu MJ, Cheng CT, Chuang TW, Kao HJ, Lu NM, Wu LC, Lee C. High prevalence of genotype 6 hepatitis C virus infection in Southern Taiwan using Abbott genotype assays. J Formos Med Assoc. 2020 Jan;119(1 Pt 3):413-419. (CMBEC-109-001)
  4. Hsiao YC, Lin SY, Chien KY, Chen SF, Wu CC, Chang YT, Chi LM, Chu LJ, Chiang WF, Chien CY, Chang KP, Chang YS, Yu JS. An immuno-MALDI mass spectrometry assay for the oral cancer biomarker, matrix metalloproteinase-1, in dried saliva spot samples. Anal Chim Acta. 2020 Mar 1;1100:118-130. (CMBEC-103-004)
  5. Wu CY, Wang RC, Chen BJ, Chen WY, Jhuang JY, Chang MC, Wu YH, Nakada N, Karube K, Chuang SS. Granuloma With an Underlying Lymphoma: A Diagnostic Challenge and a Wider Histologic Spectrum Including Adult T-Cell Leukemia/Lymphoma. Appl Immunohistochem Mol Morphol. 2020 Apr;28(4):316-324. (CMBEC-108-004)
  6. Liu CY, Chen BJ, Chuang SS; Taiwan Hematopathology Study Group. Malignant effusions from extranodal NK/T-cell lymphomas are frequently of anaplastic morphology with azurophilic granules and of T-cell lineag. Diagn Cytopathol. 2020 May;48(5):453-463. (CMBEC-108-006)
  7. Chang YT, Chu LJ, Liu YC, Chen CJ, Wu SF, Chen CH, Chang IY, Wang JS, Wu TY, Dash S, Chiang WF, Chiu SF, Gou SB, Chien CY, Chang KP, Yu JS. Verification of Saliva Matrix Metalloproteinase-1 as a Strong Diagnostic Marker of Oral Cavity Cancer. Cancers (Basel). 2020 Aug 13;12(8):2273. (CMBEC-103-004)
  8. Huang LY, Hsieh YP, Wang YY, Hwang DY, Jiang SS, Huang WT, Chiang WF, Liu KJ, Huang TT. Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model. Int J Mol Sci. 2020 Oct 31;21(21):8171. (CMBEC-106-004)
  9. Lee CH, Hung PF, Liu KJ, Chung HL, Yang WC, Hsu KC, Fong TH, Lo HJ, Chen YP, Yang JR, Yen CY. LDOC1 Suppresses Microbe-Induced Production of IL-1β in Human Normal and Cancerous Oral Cells through the PI3K/Akt/GSK-3β Axis. Cancers (Basel). 2020 Oct 27;12(11):3148. (CMBEC-106-009)
  10. Chang WT, Wu NC, Shih JY, Hsu CH, Chen ZC, Cheng BC. Right ventricular reserve post mitral valve repair is associated with heart failure hospitalization. Pulm Circ. 2020 Dec 13;10(4):2045894020943858. (CMBEC-106-005)
  11. Tung HD, Lee PL, Chen JJ, Kuo HT, Sheu MJ, Cheng CT, Chuang TW, Kao HJ, Hou CY, Tsai HH, Wu LC, Lee C. Geographic variation of genotype 6 hepatitis C virus infection in an endemic area of southern Taiwan. J Formos Med Assoc. 2020 Dec;119(12):1876-1880. (CMBEC-107-009)

2021

  1. Lin YW, Chen CY, Shih JY, Cheng BC, Chang CP, Lin MT, Ho CH, Chen ZC, Fisch S, Chang WT. Dapagliflozin Improves Cardiac Hemodynamics and Mitigates Arrhythmogenesis in Mitral Regurgitation-Induced Myocardial Dysfunction. J Am Heart Assoc. 2021 Apr 6;10(7):e019274. (CMBEC-106-005)
  2. Chang ST, Chen SW, Chen BJ, Pan ST, Karube K, Chuang SS. Aberrant TTF-1 Expression in Peripheral T-Cell Lymphomas: A Diagnostic Pitfall. Int J Surg Pathol. 2021 Apr;29(2):165-168. (CMBEC-107-007)
  3. Chen CW, Yang CH, Lin YH, Hou YC, Cheng TJ, Chang ST, Huang YH, Chung ST, Chio CC, Shan YS, Cheng HC, Chang WT. The Fibronectin Expression Determines the Distinct Progressions of Malignant Gliomas via Transforming Growth Factor-Beta Pathway. Int J Mol Sci. 2021 Apr 6;22(7):3782. (CMBEC-107-013)
  4. Tung HD, Lee PL, Chen JJ, Kuo HT, Sheu MJ, Cheng CT, Chuang TW, Kao HJ, Wu YH, Pang MG, Lin CH, Hou CY, Tsai HH, Wu LC, Lee C. Hepatitis C Virus Subtypes Novel 6g-Related Subtype and 6w Could Be Indigenous in Southern Taiwan with Characteristic Geographic Distribution. Viruses. 2021 Jul 7;13(7):1316. (CMBEC-107-009)
  5. Wu YH, Huang YF, Chang TH, Chen CC, Wu PY, Huang SC, Chou CY. COL11A1 activates cancer-associated fibroblasts by modulating TGF-β3 through the NF-κB/IGFBP2 axis in ovarian cancer cells. Oncogene. 2021 Jul;40(26):4503-4519. (CMBEC-108-009)
  6. Chen JW, Wu JH, Chiang WF, Chen YL, Wu WS, Wu LW. Taxonomic and Functional Dysregulation in Salivary Microbiomes During Oral Carcinogenesis. Front Cell Infect Microbiol. 2021 Sep 16;11:663068. (CMBEC-107-005)
  7. Yu WH, Li CH, Wang RC, Yeh CY, Chuang SS. Machine Learning Based on Morphological Features Enables Classification of Primary Intestinal T-Cell Lymphomas. Cancers (Basel). 2021 Oct 30;13(21):5463. (CMBEC-107-006)
  8. Hong CM, Lin YY, Liu CJ, Lai YY, Yeh SH, Yang HC, Kao JH, Hsu SJ, Huang YH, Yang SS, Kuo HT, Cheng PN, Yu ML, Chen PJ. Drug Resistance Profile and Clinical Features for Hepatitis C Patients Experiencing DAA Failure in Taiwan. Viruses. 2021 Nov 17;13(11):2294. (CMBEC-109-002)
  9. Wu YH, Huang YF, Chang TH, Wu PY, Hsieh TY, Hsiao SY, Huang SC, Chou CY. miR-335 Restrains the Aggressive Phenotypes of Ovarian Cancer Cells by Inhibiting COL11A1. Cancers (Basel). 2021 Dec 13;13(24):6257. (CMBEC-108-009)