The Chi Mei Medical Center established the Clinical Gene Sequencing Center under the Department of Pathology as early as 2014, providing a gene testing platform that combines high technical expertise, stable testing quality, and clinical utility. This center offers molecular tumor testing and companion diagnostics for cancers such as brain tumors, breast cancer, lung cancer, and gastrointestinal cancers to assist in cancer diagnosis and monitoring.

  In 2017, with support from the hospital, Chi Mei Medical Center built a Precision Medicine Laboratory tailored to its needs. This laboratory enhanced its gene sequencing capabilities by adding a next-generation sequencing (NGS) platform, enabling large-scale data analysis to align with the rapid development of new drugs and support precise treatment choices. Additionally, an immunomagnetic depletion analyzer was introduced to measure trace amounts of tau protein and amyloid-beta in the bloodstream, facilitating preventive screening for Alzheimer's disease and mild cognitive impairment. The lab also installed a high-performance liquid chromatography system (UPLC) for vitamin analysis and an inductively coupled plasma mass spectrometer (ICP-MS) for multi-element and heavy metal testing.

  In 2020, the center introduced liquid chromatography-tandem mass spectrometry (LC-MS/MS) for therapeutic drug monitoring and vitamin analysis. The lab is continuously expanding its metabolomics testing, aiming to deliver even more accurate and reliable testing services.

  In response to advancements in precision medicine, Chi Mei Medical Center launched its Precision Medicine Center on October 1, 2021, under the leadership of Dr. Yu-Feng Tian, who serves as the center's director and Vice President of Medical Affairs. The center includes a Core Laboratory for Precision Medicine and collaborates with clinical precision medicine departments to advance precision healthcare. In the same year, high-throughput multi-gene sequencing analysis equipment was introduced, using next-generation sequencing and AI-driven big data analysis to provide comprehensive clinical cancer gene data analysis, significantly enhancing the center's service capacity and expertise in precision medicine.

  The Precision Medicine Center combines advanced genomics and metabolomics technologies, including high-throughput gene sequencing, molecular diagnostics, and liquid chromatography-tandem mass spectrometry (LC-MS/MS). By focusing on individual genetic profiles, we provide precise testing that aids clinical diagnosis and treatment planning, supporting the medical team in designing the most suitable treatment plan to ensure personalized healthcare for each patient.

Genomics

1. Next Generation Sequencing, NGS
   Utilizing high-throughput gene sequencing technology, we comprehensively analyze patients' genetic information. This data can identify genetic mutations, predict disease risks, and facilitate personalized treatment planning, ensuring each patient receives the most effective care.
2. Molecular Tumor Board
   Our Molecular Tumor Board comprises a multidisciplinary team of experts who conduct in-depth discussions and analyses for complex and refractory cancer cases. This ensures that each patient’s treatment plan is thoroughly evaluated and optimized.
3. Cancer Genetic Counseling Clinic
   We offer a dedicated cancer genetic counseling clinic, providing professional advice and interpreting test results for patients who require genetic testing.

Metabolomics

1. ImmunoMagnetic Reduction, IMR
   IMR technology detects trace levels of biomarkers such as tau protein and β-amyloid protein in blood, primarily used for preventive screening assessments of Alzheimer’s disease and mild cognitive impairment.
2. Ultra-Performance Liquid Chromatography, UPLC
   UPLC technology enables efficient analysis of micronutrients such as vitamins, delivering rapid and accurate results that help in assessing and managing patients' nutritional status.
3. Inductively Coupled Plasma Mass Spectrometry, ICP-MS
   ICP-MS technology measures trace elements and heavy metals with high sensitivity and accuracy, identifying and quantifying even the lowest concentrations of elements in samples, crucial for environmental exposure and toxin monitoring.
4. Liquid chromatography–mass spectrometry, LC-MS/MS
   Widely used for therapeutic drug monitoring and vitamin analysis, LC-MS/MS technology efficiently separates and identifies multiple components in complex samples, providing reliable data for drug efficacy monitoring and nutritional status assessment.

These specialized services and technologies allow us to lead in precision medicine, offering the most advanced and effective medical care for our patients.