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重要成果

獎項與榮譽

獎項與榮譽

Awards and Honors

 

 
2017-2019
The best annual research award in Chi-Mei Medical Center
 
2018
TA-YOU WU MEMORIAL AWARD (吳大猷先生紀念獎)
 
2017
Young investigator award in Taiwan Society of Cardiology
 
2023
The Phi Tau Phi Scholastic Honor (斐陶斐榮譽會員)

 

 Manuscripts associated with MR-induce heart failure

  1. Lee WC, Lin YW, Shih JY, Chen ZC, Wu NC, Chang WT(Corresponding author). Ivabradine could not decrease mitral regurgitation triggered atrial fibrosis and fibrillation compared with carvedilol. ESC Heart Fail. 2023 Nov 14. doi: 10.1002/ehf2.14577. Online ahead of print. (IF:3.612)
  2. Chang WT, Lin YW, Chen CY, Chen ZC, Shih JY, Wu CC, Luo CY, Liu PY. Mineralocorticoid Receptor Antagonists Mitigate Mitral Regurgitation-Induced Myocardial Dysfunction. 2022 Sep;11(17):2750 (IF:766)
  3. Lin YW, Chen CY, Shih JY, Cheng BC, Chang CP, Lin MT, Ho CH, Chen ZC, Fisch S, Chang WT (Corresponding author). Dapagliflozin Improves Cardiac Hemodynamics and Mitigates Arrhythmogenesis in Mitral Regurgitation-Induced Myocardial Dysfunction.J Am Heart Assoc. 2021 Mar 20:e019274. (IF:6.107).
  4. Chang WT, Wu NC, Shih JY, Hsu CH, Chen ZC, Cheng BC. Right ventricular reserve post mitral valve repair is associated with heart failure hospitalization. Pulm Circ. 2020 Dec 13;10(4):
  5. (IF:2.886)
  6. Hu YN, Chang WT, Roan JN. Early bioprosthesis failure in mitral valve replacement. J Card Surg. 2021 Jan;36(1):307-308. (IF:1.778)
  7. Chang HY, Chang WT, Liu YW. Application of transthoracic echocardiography in patients receiving intermediate- or high-risk noncardiac surgery. PLoS One. 2019 Apr 25;14(4):e0215854. (IF:3.752)
  8. Chang WT, Chen JS, Hung YK, Tsai WC, Juang JN, Liu PY. Characterization of aging-associated cardiac diastolic dysfunction. PLoS One. 2014 May 28;9(5):e97455. (IF:3.752)

Manuscripts associated with Cardio-Oncology

  1. Chang WT,Jhih-Yuan Shih, Yu-Wen Lin, Zhih-Cherng Chen, Wei-Chih Kan, Tsung-Hsien Lin, Chon-Seng Hong. Dapagliflozin Protects Against Doxorubicin-induced Cardiotoxicity by Restoring STAT3. Archives of Toxicology. 2022 Jul;96(7):2021-2032. (IF:5.15)
  2. Chang WT, Chen PW, Lin HW, Lin SH, Li YH. Risks of trastuzumab-related cardiotoxicity in breast cancer patients in Taiwan. ESC Heart Fail. 2021 Dec;8(6):5149-5158. (IF: 3.612) . Chang WT, et al. Layer-specific distribution of myocardial deformation from anthracycline-induced cardiotoxicity in patients with breast cancer.Int J Cardiol. 2020 Jul 15;311:64-70 (IF:4.03)
  3. Shih JY, Lin YW, Fisch S, Cheng JT, Kang NW, Hong CS, Chen ZC,Chang WT (Corresponding). Dapagliflozin Suppresses ER Stress and Improves Subclinical Myocardial Function in Diabetes: from Bedside to Bench.Diabetes. 2021 Jan;70(1):262-267. (IF:7.273)
  4. Chang WT, Lin YW, Ho CH, Chen ZC, Liu PY, Shih JY. Dapagliflozin suppresses ER stress and protects doxorubicin-induced cardiotoxicity in breast cancer patients. Arch Toxicol.2020 Nov 19 (IF:5.98)

Manuscripts associated with pulmonary arterial hypertension

  1. Chang WT, Lee WC, Lin YW, Shih JY, Hong CS, Chen ZC, Chu CY, Hsu CH. Transpulmonary Expression of Exosomal microRNAs in Idiopathic and Congenital Heart Disease-Related Pulmonary Arterial Hypertension. J Am Heart Assoc. 2023 Dec 5;12(23):e031435. (IF:6.107)
  2. Liao CT, Toh HS, Yang CT, Hsu CY, Lee MC, Chang WT, et al. Economic evaluation of new blood pressure target for hypertensive patients in Taiwan according to the 2022 hypertension clinical practice guidelines of the Taiwan society of cardiology: a simulation modeling study.Hypertens Res. 2022 Oct 14 (IF:5.52)
  3. Chang WT, Jhih-Yuan Shih, Yu-Wen Lin, Tzu-Ling Huang, Zhih-Cherng Chen, Chi-Long Chen, Jan-Show Chu, Ping Yen Liu MiR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts. Aging (Albany NY). 2022 Jul 28;14(14):5925-5945. (IF:5.95)
  4. Chang WT, Fisch S, Dangwal S, Mohebali J, Fiedler AG, Chen M, Hsu CH, Yang Y, Qiu Y, Alexander KM, Chen FY, Liao R. MicroRNA-21 regulates right ventricular remodeling secondary to pulmonary arterial pressure overload.J Mol Cell Cardiol. 2021 Feb 3:S0022-2828(21)00021-3. (IF:4.13)
  5. Chang WT, Fisch S, Dangwal S, Chen M, Cheng S, Chen ZC, Liao R. Angiotensin II blockers improve cardiac coronary flow under hemodynamic pressure overload.Hypertens Res. 2021 Jul;44(7):803-812 (IF:5.525)

Manuscripts associated with limb ischemia

  1. Chang WT, Yu-Wen Lin, Po-Sen Huang, You-Cheng Lin, Shih-Ya Tseng, Ting-Hsing Chao, Zhih-Cherng Chen, Jhih-Yuan Shih, Chon-Seng Hong. Deletion of miR-21 impairs neovascularization following limb ischemia: from bedside to bench. Frontiers in Cardiovascular Medicine.2022 Apr 26;9:826478. (IF:5.05).
  2. Chang WT, Lin YC, Hong CS, Huang PS, Lin YW, Chen ZC, Lin TH, Chao TH. Effects of STAT3 on aging-dependent neovascularization impairment following limb ischemia: from bedside to bench.

Aging (Albany NY). 2022 Jun 13;14(11):4897-4913. (IF:5.955)

Other manuscripts

  1. Chang WT, Wu CC, Liao IC, Lin YW, Chen YC, Ho CH, Lee WC, Lin YC, Chen ZC, Shih JY, Wu NC, Kan WC. Dapagliflozin protects against doxorubicin-induced nephrotoxicity associated with nitric oxide pathway-A translational study. Free Radic Biol Med. 2023 Nov 1;208:103-111. (IF:8.101)
  2. Chang WT, Wu SN. Effectiveness of Columbianadin, a Bioactive Coumarin Derivative, in Perturbing Transient and Persistent INa..Int J Mol Sci. 2021 Jan 9;22(2):E621. (IF:4.556)
  3. Chang WT, Wu SN. Characterization of Direct Perturbations on Voltage-Gated Sodium Current by Esaxerenone, a Nonsteroidal Mineralocorticoid Receptor Blocker. 2021 May 13;9(5):549. (IF:4.757)
  4. Gupta S, and Chang WT et al.Acute kidney injury in patients treated with immune checkpoint inhibitors. I CPi-AKI Consortium. J Immunother Cancer. 2021 Oct;9(10):e003467 (IF:13.75)
  5. Liao CT, Yang CT, Toh HS, Chang WT et al.Cost-effectiveness evaluation of add-on dapagliflozin for heart failure with reduced ejection fraction from perspective of healthcare systems in Asia-Pacific region. Cardiovasc Diabetol. 2021 Oct 9;20(1):204. (IF:9.95)
  6. Chang WT, Liu PY, Gao ZH, Lee SW, Lee WK, Wu SN. Evidence for the Effectiveness of Remdesivir (GS-5734), a Nucleoside-Analog Antiviral Drug in the Inhibition of IK(M)or IK(DR) and in the Stimulation of I MEP. Front Pharmacol. 2020 Jul 21;11:1091. (IF:4.4)
  7. Chang WT, Wu SN. Inhibitory Effectiveness of Gomisin A, a Dibenzocyclooctadiene Lignan Isolated from Schizandra chinensis, on the Amplitude and Gating of Voltage-Gated Na+ Current. Int J Mol Sci. 2020 Nov 21;21(22):8816. (IF:4.556)
  8. Chang WT, Liu PY, Wu SN. High Capability of Pentagalloylglucose (PGG) in Inhibiting Multiple Types of Membrane Ionic Currents.Int J Mol Sci. 2020 Dec 9;21(24):E9369 (IF:4.556)
  9. Chang WT, Ho CH, Chang CL, Chen ZC. Impact of warfarin on cardiac and cerebrovascular events following bioprosthetic aortic valve replacement– a nationwide cohort study. J Thorac Cardiovasc Surg 2020 May;159(5):1730-1739.e1. (IF: 4.88)
  10. Chang WT, Lo YC, Gao ZH, Wu SN. Evidence for the Capability of Roxadustat (FG-4592), an Oral HIF Prolyl-Hydroxylase Inhibitor, to Perturb Membrane Ionic Currents: An Unidentified yet Important Action.Int J Mol Sci. 2019 Nov 29;20(23):6027. (IF: 4.556)